22ReportsErkan D. Lupus anticoagulant-hypoprothrombinemia syndrome associated with systemic lupus erythematosus: report of 2 cases and review of literature. Lupus 1999Taddio A. Steady improvement of prothrombin levels after cyclophosphamide therapy in pediatric lupus anticoagulant hypoprothrombinemia syndrome (LAHPS). Clin Rheumatol. 2007Galli M. Antiprothrombin antibodies: detection and clinical significance in the antiphospholipid syndrome. Blood. 1999
23Lupus anticoagulant-hypoprothrombinemia syndrome Bleeding - rare manifestation of antiphospholipid syndromenearly always due to factor II deficiencyMechanism: non-neutralizing antibodies bind prothrombin, resulting in the rapid clearance of prothrombin-anti-prothrombin antibody complexes from circulation
24Lupus anticoagulant-hypoprothrombinemia syndrome SLE/healthy children after viral infectionMost of patients either had LA-HPS at initial diagnosis of SLE or within a year of onset of symptomsCorticosteroid are to decrease the clearance of the prothrombin-antiprothrombin antibody complexesMost of the cases responded successfully to steroids.