THE MALE REPRODUCTIVE SYSTEM K. SRIPANIDKULCHAI.PhD. DEPARTMENT OF ANATOMY FACULTY OF MEDICINE KHON KAEN UNIVERSITY

วัตถุประสงค์ เมื่อสิ้นสุดการเรียนแล้ว นักศึกษาสามารถ 1. บอกหน้าที่ของระบบสืบพันธุ์เพศชายได้ 2. บอกชื่ออวัยวะที่ประกอบเป็นระบบสืบพันธุ์เพศชายได้ 3. อธิบายกายวิภาคศาสตร์ของอวัยวะในระบบสืบพันธุ์เพศชายได้ 4. อธิบายการสร้างอสุจิ โครงสร้างของอสุจิได้ 5. อธิบายทางเดินของอสุจิได้

THE MALE REPRODUCTIVE ORGANS Primary sex organ : Testis Secondary sex organ : Reproductive tract -Ductulus efferens -Ductus epididymis -Ductus deferens -Ejaculartory duct -Urethra : Accessory sex gland -Seminal vesicle -Prostate gland -Bulbourethral gland -Urethral gland

The testis Structure of the testis - เป็นต่อมรูปไข่ - ขนาด 2.5 x 4 เซนติเมตร - บรรจุอยู่ในถุงอัณฑะ (scrotum) - ภายในอัณฑะแบ่งเป็น ช่องรูปลิ่มเล็กๆ ประมาณ 250 - 300 ช่อง แต่ละช่องบรรจุ seminiferous tubule

SCROTUM Skin Superficial (Dartos ) fascia External spermatic fascia Middle spermatic fascia Cremasteric muscle Internal spermatic fascia Tunica vaginalis Visceral & Parietal layers

DESCENT OF TESTIS

INDIRECT INGUINAL HERNIA PATENT PROCESSUS VAGINALIS INDIRECT INGUINAL HERNIA FUNICULAR PROCESS HERNIATION IN FUNICULAR PROCESS

SPERMATIC CORD SUSPEND TESTIS COVERING CONTENTS VASECTOMY EXTERNAL SPERMATIC FASCIA MIDDLE SPERMATIC FASCIA (CREMASTERIC FASCIA) CREMASTERIC MUSCLE (INTERNALABDOMINAL OBLIQUE + TRANSVERSUS ABDOMINIS) INTERNAL SPERMATIC FASCIA CONTENTS DUCTUS DEFERENS TESTICULAR ARTERY PAMPINIFORM PLEXUS CREMASTERIC ARTERY GENITOFEMORAL NERVE LYMPHATIC VESSEL FAT VASECTOMY SUPERFICIAL INGUINAL RING

CONTENTS OF THE SPERMATIC CORD

TESTICULAR ARTERY

Primary sex organ Testis Covering : Tunica vaginalis : Tunica albuginea : Tunica vasculosa Stroma : Loose connective tissue : Septum : Medastinum testis : Leydic ecll Parenchyma : Seminiferous epithelium

MICROSCOPIC VIEW OF TESTIS SPERMATIC FASCIA &CREMASTERIC MUSCLE TUNICA VAGINALIS TUNICA ALBUGINEA TUNICA VASCULOSA CONNECTIVE TISSUE SEPTUM PARENCHYMA OF TESTIS SEMINIFEROUS TUBULE SEMINIFEROUD EPITHELIUM

SEMINIFEROUS EPITHELIUM

LOOSE CONNECTIVE TISSUE SPERMATOGENIC CELLS SPERMATOGONIUM PRIMARY SPERMATOCYTE SPERMATID SERTOLI CELL MYOID CELL BASEMENT MEMBRANE LOOSE CONNECTIVE TISSUE

LYDIG CELL

Parenchyma : Seminiferous epithelium :Convoluted seminiferous tubule : Spermatogenic cell Spermatogonia,Primary & Secondary Spermatocyte,spermatid,Sperm : Sertoli cell : Tubulus rectus : Rete testis

Spermatogenesis 1. Spermatogonial phase 2. Spermatocyte phase 3. Spermatid phase

Spermiogenesis GOLGI PHASE CAP PHASE ACROSOMAL PHASE MATURATION PHASE 1. FLAGELLA DEVELOPMENT 2. ACROSOMAL DEVELOPMENT GOLGI PHASE CAP PHASE ACROSOMAL PHASE MATURATION PHASE

โครงสร้างตัวอสุจิ

SERTOLI CELL

SERTOLI’S CELL FUNCTION COLUMNAR CELL BRIDGE CELL OCCLUDING (TIGHT) JUNCTION 1.BASOLATERAL AND ADLUMINALCOMPARTMENTS 2.BLOOD-TESTIS BARRIER FUNCTION 1. SUPPORT,PROTECT ,NOURICH DEVELOPING SPERMATOGENIC CELLS 2. RESIDUAL BODY PHAGOCYTOSIS 3 ACTIN MEDIATE SPERMIATION 4. PRODUCE TESTICULAR FLUID 5. SECRETE ABP INHIBIN ACTIVIN MIS

Male reproductive tract Intratesticular tract Tubulus rectus Rete testis Extratesticular tract Ductulus efferens Ductus epididymis Ductus deferens Ejaculatory duct Urethra

RETE TESTIS SEMINIFEROUS TUBULE

SIMPLE CUBOIDAL(COLUMNAR) EPITHELIUM & 1 CILIA

EFFERENT DUCTULE

SIMPLE COLUMNAR EPITHELIUM 1. PRINCIPAL CELL & STEREOCILIA : RESORPTION 2.CLIATED CELL:NONMOTILE SPERM TRANSPORT 3. BASAL CELL SCALLOPED OUTLINED EPITHELIUM

EPIDIDYMIS HEAD(CAPUT) BODY(CORPUS) TAIL(CAUDA) EFFERENT DUCTULE DUCTUS EPIDIDYMIS

PSEUDOSTRATIFIED COLUMNAR EPITHELIUM WITH BRANCHED STEREOCILIA

SPERM MATURATION CAPACITATION FEMALE GENITAL TRACT

DUCTUS DEFERENS

SPERMATIC CORD

PSEUDOSTRATIFIED COLUMNAR EPITHELIUM DUCTUS DEFERENS MUCOSA PSEUDOSTRATIFIED COLUMNAR EPITHELIUM LAMINA PROPIA MUSCULAR LAYER INNER LONGITUDINAL MIDDLE CIRCULAR OUTER LONGITUDINAL ADVENTITIA

ACESSORY MALE SEX GLANDS SEMINAL VESICLE PROSTATE GLANDS BULBOURETHRAL GLAND URETHRAL GLAND

SEMINAL VESICLE

SAGITTAL SECTION OF THE MALE PERINEUM

POSTERIOR SURFACE OF URINARY BLADDER AMPULLA OF THE DUCTUD DEFERENS URETER SEMINAL VESICLE

OUTER CONNECTIVE TISSUE LAYER MIDDLE MUSCULAR LAYER INNER FOLDED MUCOSA

SIMPLE COLUMNAR EPITHELIUM

SEMINAL VESICLE SECRETION 60% OF SEMEN VICUS YELLOWISH FLUID RICH IN FRUCTOSE : MAIN ENERGY SOURCE OF SPERM PROSTAGLANDIN SEMINAL VESICLE-SPECIFIC PROTEIN FLAVONE : UV FLUORESCENCE

PROSTATE GLAND

SAGITTAL SECTION OF THE MALE PERINEUM

POSTERIOR SURFACE OF URINARY BLADDER AMPULLA OF THE DUCTUD DEFERENS URETER SEMINAL VESICLE PROSTATE GLAND

TUBULOALVEOLAR GLANDS PROSTATE GLAND 30-50 COMPOUND TUBULOALVEOLAR GLANDS MUCOSAL GLAND SUBMUCOSAL GLAND MAIN GLAND

POSTERIOR WALL OF PROSTATIC URETHRA URETHRAL CREST COLLICULUS SEMINALIS (VERUMONTANUM) PROSTATIC UTRICLE OPENING OF EJACULATORY DUCT PROSTATIC SULCUS OPENING OF PROSTATIC DUCT

COMPOUND TUBULOALVEOLAR GLAND SIMPLE SQUAMOUS EPITHELIUM SIMPLE COLUMNAR EPITHELIUM PSEUDOSTRATIFIED COLUMNAR EPITHELIUM FIBROMUSCULAR STROMA

(PROSTATIC CONCRETION) COPORA AMYLACEA (PROSTATIC CONCRETION)

SIMPLE COLUMNAR EPITHELIUM LAMINA PROPIA SMOOTH MUSCLE

PROSTATIC JUICE 1/3 OF SEMEN MILKY WHITE LIQUID CLOTTING THE SEMEN LOW PROTIENS ACID PHOSPHATASE FIBRINOLYSIN FERTILYZING PROMOTING PEPTIDE(FPP) CITRIC ACID AMYLASE ZINC pH 6.5

CLINICAL SIGNIFICANCE BENIGN PROSTATIC HYPERTHROPHY(BPH) MUCOSAL GLAND URINARY OBSTRUCTION URINARY RETENTION CYSTITIS PYELONEPHRITIS PROSTATE CANCER SUBMUCOSAL AND MAIN GLANDS INCREASE IN PROSTATE ACID PHOSPHATASE AND PROSTAETE-SPECIFIC ANTIGEN(PSA)

BULBOURETHRAL (COWPER’S) GLAND

SAGITTAL SECTION OF THE MALE PERINEUM

CORONAL SECTION

COMPOUND TUBULOALVEOLAR GLAND PEA SIZE CLEAR MUCOUS SECRETION LUBRICATE URETHRA PRESEMINAL FLUID CONTENTS: GALACTOSE SOME SIALIC ACID BASIC pH

URETHAL (LITTRE’S) GLAND

INTRAEPITHELIAL GLAND CLEAR MUCUS LUBRIATE PENILE URETHRA PRESEMINAL FLUID

The Penis

TRANSVERSE SECTION OF THE PENIS SKIN SUPERFICIAL(DARTOS) FASCIA DEEP(BUCK’S) FASCIA TUNICA ALBUGINEA ERECTILE TISSUE CORPORA CAVERNOSA CORPUS SPONGIOSUM PENILE URETHRA

ERECTION

INHIBT PHOSPHODIESTERASE SILDENAFIL(VIAGRA) INHIBT PHOSPHODIESTERASE cGMP

THE MALE URETHRA 20 CM. PROSTIC URETHRA MEMBRANOUS URETHRA PENILE URETHRA

EJACULATION