ดาวน์โหลดงานนำเสนอ
งานนำเสนอกำลังจะดาวน์โหลด โปรดรอ
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M. Sc. In Pharm (Pharmacology)
Antiamebic drugs Pawitra Pulbutr M. Sc. In Pharm (Pharmacology)
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วัตถุประสงค์เชิงพฤติกรรม
มีความเข้าใจและอธิบายถึงกลไกการออกฤทธิ์, เภสัชจลนศาสตร์ และอาการไม่พึงประสงค์ของยา Antiamebic มีความเข้าใจและอธิบายถึงการนำไปใช้ประโยชน์ทางคลินิกของยา Antiamebic
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Entamoeba histolytica infection .... Protozoa
Amebiasis Entamoeba histolytica infection .... Protozoa
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Forms of Amebiasis 1. Asymptomatic intestinal infection
2. Mild to moderate intestinal infection 3. Severe intestinal infection (dysentery) 4. Hepatic abscess 5. Ameboma or extrahepatic forms of amebiasis
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Antiamebic drugs Kill... trophozoite
Tissue Amebicides Active at intestinal wall, liver, other tissues Not effective in lumen Nitroimidazole Metronidazole, Tinidazole, Nimorazole, Ornidazole Emetines Chloroquine...Liver
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Antiamebic drugs Luminal amebicides Active in intestinal lumen
Dichloroacetamides Diloxanides furoate Halogenated hydroxyquinolines iodoquinol clioquinol Antibiotics … Paromomycin, Tetracyclines, Erythromycin
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Metronidazole Tissue amebicides Most effective for invasive amebiasis Expected mechanism... Toxic oxygen products Destroy trophozoite DNA
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Metronidazole Clinical uses Drug of choice for intestinal amebiasis extraintestinal amebiasis congenital trichomiasis
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Other Nitroimidazole Tinidazole Nimorazole Ornidazole Longer half life Metronidazole = Flagyl® Tinidazole = Fasigyn®
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Emetine & Dehydroemetine
tissue amebicide Irreversible block of protein synthesis Block ribosome translocation on mRNA Parenterally Accumulate in liver, lung, spleen, kidney
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Chloroquine High level in liver use in ... Amebic liver abscess...ONLY
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Luminal amebicides Diloxanide furoate
direct amebicide…unknown mechanism dissociate in lumen into diloxanide & furoic acid 90% diloxanide absorption Unabsorbed diloxanide....Active luminal amebicide
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Iodoquinol iodoquinol = diiodohydroxyquin luminal amebicide Unknown mechanism of action Interfere thyroid function test decrease 131I uptake Alternative to diloxanide furoate
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Treatment amebiasis Asymptomatic intestinal infection not necessary in endemic area... Reinfection Luminal amebicide DOC....diloxanide furoate
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Tissue amebicide + Luminal amebicide
Treatment amebiasis Mild to moderate intestinal infection Severe intestinal infection (dysentery) Hepatic abscess / other extrahepatic infection Tissue amebicide + Luminal amebicide DOC Metronidazole + diloxanide furoate
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