งานนำเสนอเรื่อง: "Situation of Zika virus infection in Thailand"— ใบสำเนางานนำเสนอ:
1 Situation of Zika virus infection in Thailand 2012-2016 Rome BUATHONG, MD., FETP., MIH.,Prev. Med. (Epidemiology)Bureau of Epidemiology,Department of Disease ControlThailand Ministry of Public Health
4 Global Zika Virus in the past 1947 - 2007 Asian lineageAfrican lineageSource : Hayes EB. Zika virus outside Africa. Emerg Infect Dis Sep
5 Discovery of Zika virus Apr 1947:The virus was isolated from sentinel rhesus monkey in Zika forest, Uganda through monitoring of yellow fever.Jan 1948:The virus was isolated from Aedes africanus mosquito in UgandaYear 1952:Human infections were found in Uganda and Tanzania.From its discovery until 2007, Zika virus infection were rare in Africa and Southeast Asia.
6 Zika virus outbreaksFrom its discovery until 2007, Zika virus infection were rare in Africa and Southeast Asia. 2007- an outbreak occurred in Yap Island, Federation States of Micronesia. Zika was first considered as an emerging disease.the outbreak occurred in French Polynesia. Complication with Guillain-Barré syndrome was suspected.May the outbreak occurred in Brazil
7 Zika virus spreading in Southern Pacific Islands and Asia 2012Philippines2010Cambodia2013Thailand2013IndonesiaSource:
8 Molecular Seq of Zika virus in South East Asia and Latin America BrazilThailandAsian lineageR. Buathong,Thailand MOPH & S. Wacharapluesadee, Chulalongkorn University
9 Zika fever in Yap Islands, 2007 Source : Mark R. Duffy et al. Zika Virus Outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009;360:
10 Zika fever in Yap Islands, 2007 Source : Mark R. Duffy et al. Zika Virus Outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009;360:
11 Zika fever in Yap Islands, 2007 Source : Mark R. Duffy et al. Zika Virus Outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009;360:
12 Epi & Clinical Characteristics of confirmed Zika fever outbreak 1st symptomT. Tantitaweewat & R. Buathong,Thailand MOPH
13 Maculopapular rash among cases These picture show MP rash in cases13T. Tantitaweewat & R. Buathong,Thailand MOPH13
14 Bilateral conjunctivitis (Red eyes) These picture show bilateral conjunctivitis with sufusion in cases.T. Tantitaweewat & R. Buathong,Thailand MOPH1414
15 Zika virus spreading in Latin America and the Caribbean Source : WHO PAHO, February 2016
16 Countries and territories with Zika virus transmission Source : ECDC, February 2016
17 Zika virus spreading in NE Brazil and Microcephaly in NB >4,000 case/2015Association and now Zika virus infection is one in many microcephaly CausationsAverage200 case/yearSource : TheLipTV, youtube.com/watch?v=zmDIoTNqJ0o and AP
21 Zika virus affected to fetus and infant Virus in the fetus brainCT Brain in microcephaly
22 Number of reported cases of microcephaly Number of reported cases of microcephaly* in full-term newborns following laboratory-confirmed Zika virus transmission — Pernambuco, Paraíba, and Bahia states, Brazil, 2015MMWR, US CDC
23 Number of reported cases of microcephaly Number of reported cases of microcephaly* in full-term newborns following laboratory-confirmed Zika virus transmission — Pernambuco, Paraíba, and Bahia states, Brazil, 2015MMWR, US CDC
24 Warm climate and outbreaks With warm weather, mosquitoes fly more and bite more.Warm weather speeds up virus replication rate in mosquitoes.
25 Alert signalOn May 2013, Canada IHR focal point notified Thai MoPH about a Canadian traveler confirmed Zika virus infection returning from ThailandA 45-year-old female Canadian stayed in Thailand during 20th Jan – 4th Feb, 2013Her onset date was 4th Feb with backache, irritable, headache when she transited at the airport in Hong Kong
26 Exported case#1 The case 45-year-old female Canadian tourist Stayed in Thailand during Jan 20th - Feb 4th, 2013Onset began Feb 4th while onboard with backache, irritable, headache, then at home chilled, rash with red eyes (suspected Measles), severe joint pain, vomiting, thrombocytopenia (suspected Dengue)Clinical long lasting for 2 ½ weeksZika virus confirmed by PCR and sequencing linage similar to Cambodia and Micronesia strain and serology confirmedSuspected area of exposure to virus: Bangkok and Phuket
33 Exported case # 4-Thai 24 year old, -Northern province, -Quarantined at Taoyuan Airport coz of fever on 10 January Clinical developed in Thailand 1 day before departure to Taiwan -Zika PCR in positive in patient’s bloodSource:
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